Ph. D. University of Kentucky (Division of Nutritional Sciences, College of Medicine;
Focus: Obesity-Induced Hypertension), 2011
M.S. University of Kentucky (Division of Nutritional Sciences, College of Medicine;
Focus: Clinical Nutrition), 2008
Human Anatomy and Physiology, Principles of Biology I, Cell and Molecular Biology
Obesity, Heart Failure, Type 2 Diabetes Mellitus
Manisha Gupte,Sultan Tousif, Jacob J. Lemon, Angelica Toro Cora, Prachi Umbarkar, and Hind Lal. Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose Intolerance.
Cells. 2022 Feb; 11(3): 559
Gupte M, Umbarkar P, Singh AP, Zhang Q, Tousif S, Lal H. Deletion of Cardiomyocyte
Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with
Maintained Heart Function in Established Obesity. Cells. 2020 Apr 30;9(5):1120.
Umbarkar P, Singh AP, Gupte M, Verma VK, Galindo CL, Guo Y, Zhang Q, McNamara JW,
Force T, Lal H. Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain
Adult Heart Homeostasis. JACC Basic Transl Sci. 2019 Jan 16;4(1):41-53.
Manisha Gupte, Samvruta Tumuluru, Jennifer Sui, Anand Prakash Singh, Prachi Umbarkar,
Shan Parikh, Firdos Ahmad, Qinkun Zhang, Thomas Force, Hind Lal. Cardiomyocyte-Specific
Deletion of GSK-3β Leads to Cardiac Dysfunction in a Diet Induced Obesity Model. Int
J Cardiol. 2018 May 15;259:145-152.
Manisha Gupte, Hind Lal, Firdos Ahmad, Douglas B Sawyer, Michael F Hill. Chronic Neuregulin-1β
Treatment Mitigates the Progression of Post-Myocardial Infarction Heart Failure in
the Setting of Type 1 Diabetes Mellitus by Suppressing Myocardial Apoptosis, Fibrosis
and Key Oxidant-Producing Enzymes. J Card Fail. 2017 Sep 1. S1071-9164(17)31159-4.
Manisha Gupte, Prachi Umbarkar, Hind Lal. Mechanistic Insights of Empagliflozin-Mediated
Cardiac Benefits: Nearing the Starting Line. Cardiovasc Drugs Ther. 2017 Jul 21.
Jason M. Spaeth*, Manisha Gupte*, Holly Cyphert, Mark Christopher Wright, Mark Magnuson,
Joseph Bass, Roland Stein. Defining a novel role for the Pdx1 transcription factor
in islet β cell maturation and proliferation during weaning. Diabetes 2017 Jul; db161516.
* equal contribution