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Manisha Gupte

Manisha Gupte

Assistant Professor


  • Contact

  • guptem@apsu.edu
  • 931-221-6437
  • Sundquist Science Complex Room SSC C225


Ph. D. University of Kentucky (Division of Nutritional Sciences, College of Medicine; Focus: Obesity-Induced Hypertension), 2011

M.S. University of Kentucky (Division of Nutritional Sciences, College of Medicine; Focus: Clinical Nutrition), 2008

Human Anatomy and Physiology, Principles of Biology I, Cell and Molecular Biology

Obesity, Heart Failure, Type 2 Diabetes Mellitus

  • Manisha Gupte, Sultan Tousif, Jacob J. Lemon, Angelica Toro Cora, Prachi Umbarkar, and Hind Lal. Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose Intolerance. Cells. 2022 Feb; 11(3): 559
  • Gupte M, Umbarkar P, Singh AP, Zhang Q, Tousif S, Lal H. Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity. Cells. 2020 Apr 30;9(5):1120.
  • Umbarkar P, Singh AP, Gupte M, Verma VK, Galindo CL, Guo Y, Zhang Q, McNamara JW, Force T, Lal H. Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain Adult Heart Homeostasis. JACC Basic Transl Sci. 2019 Jan 16;4(1):41-53.
  • Manisha Gupte, Samvruta Tumuluru, Jennifer Sui, Anand Prakash Singh, Prachi Umbarkar, Shan Parikh, Firdos Ahmad, Qinkun Zhang, Thomas Force, Hind Lal. Cardiomyocyte-Specific Deletion of GSK-3β Leads to Cardiac Dysfunction in a Diet Induced Obesity Model. Int J Cardiol. 2018 May 15;259:145-152.
  • Manisha Gupte, Hind Lal, Firdos Ahmad, Douglas B Sawyer, Michael F Hill. Chronic Neuregulin-1β Treatment Mitigates the Progression of Post-Myocardial Infarction Heart Failure in the Setting of Type 1 Diabetes Mellitus by Suppressing Myocardial Apoptosis, Fibrosis and Key Oxidant-Producing Enzymes. J Card Fail. 2017 Sep 1. S1071-9164(17)31159-4.
  • Manisha Gupte, Prachi Umbarkar, Hind Lal. Mechanistic Insights of Empagliflozin-Mediated Cardiac Benefits: Nearing the Starting Line. Cardiovasc Drugs Ther. 2017 Jul 21.
  • Jason M. Spaeth*, Manisha Gupte*, Holly Cyphert, Mark Christopher Wright, Mark Magnuson, Joseph Bass, Roland Stein. Defining a novel role for the Pdx1 transcription factor in islet β cell maturation and proliferation during weaning. Diabetes 2017 Jul; db161516. * equal contribution