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Alex Zhang

Assistant ProfessorAlex Zhang photo

Sundquist Science Complex, Room D217
P.O. Box 4718
Clarksville, TN 37044
(931) 221-6499
email: zhanga@apsu.edu


Ph.D. South Dakota State University (Veterinary Microbiology), 2013

M.S. South Dakota State University (Microbiology), 2009

B.S. Huazhong Agricultural University (Veterinary Medicine), 2006


Principles of Microbiology/Lab and General Microbiology/Lab

Research Interests

Microbiology, bacterial infectious diseases, vaccine development, epidemiology, bacterial genomics

Selected Publications

Zhu N, Zhang C, Prakash A, Hou Z, Liu W, She W, Morris A, Sik Kim K. Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR. EMBO Mol Med. 2021 Jan 21:e12651. doi: 10.15252/emmm.202012651. PMID: 33474818.

Zhang C*, Guerra JA*, Bard JE, Yergeau D, Halasa N, Gómez-Duarte OG. Comparative genomic analysis of a Shiga toxin-producing Escherichia coli (STEC) O145:H25 associated with a severe pediatric case of hemolytic uremic syndrome in Davidson County, Tennessee, US. BMC Genomics. 2020;21(1):564. Published 2020 Aug 17. doi:10.1186/s12864-020-06967-3. * equal contribution

Farfán-García AE, Imdad A, Zhang C, et al. Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. PLoS Negl Trop Dis. 2020;14(6):e0008375. Published 2020 Jun 30. doi:10.1371/journal.pntd.0008375

Zhu N, Liu W, Prakash A, Zhang C, Kim KS. Targeting E. coli invasion of the blood-brain barrier for investigating the pathogenesis and therapeutic development of E. coli meningitis. Cell Microbiol. 2020;22(10):e13231. doi:10.1111/cmi.13231

Aamer Imdad, Monique A. Foster, Junaid Iqbal, Christopher Fonnesbeck, Daniel C. Payne, Chengxian Zhang, James D. Chappell, Natasha Halasa, and Oscar G. Gómez-Duarte. Diarrheagenic Escherichia coli and acute gastroenteritis in children in Davidson County, Tennessee, United States: A case-control study. The Pediatric Infectious Disease Journal. 2018 Jan 16. doi: 10.1097/INF.0000000000001908.

Chengxian Zhang*, Ana Elvira Farfán-García*, Aamer Imdad, Monica Arias-Guerrero, Nayibe Sanchez-Alvarez, Rikhil Shah, Junaid Iqbal, Maria Tamborski, and Oscar G. Gómez-Duarte. Case-control pilot study on acute diarrheal disease in a geographically defined pediatric population in a middle-income country. International Journal of Pediatrics. 2017:6357597. doi: 10.1155/2017/6357597. Epub 2017 Aug 10. * equal contribution.

Chengxian Zhang, Junaid Iqbal, Oscar G. Gómez-Duarte. Murine immunization with CS21 pili or LngA major subunit of enterotoxigenic Escherichia coli (ETEC) elicits systemic and mucosal immune responses and inhibits ETEC gut colonization. Veterinary Microbiology. 2016 Feb 6. pii: S0378-1135(16)30026-8. doi: 10.1016/j.vetmic.2016.02.001.

 laudia Guevara, Chengxian Zhang, Jennifer A. Gaddy, Junaid Iqbal, Julio Guerra, David P. Greenberg, Michael D. Decker, Nicholas Carbonetti, Timothy D. Starner, Paul B. McCray Jr, Frits R. Mooi & Oscar G. Gómez-Duarte. Highly differentiated human airway epithelial cells: a model to study host cell-parasite interactions in pertussis. Infectious Diseases (London, England). 2015 Oct 22:1-12.

Monique A. Foster, Junaid Iqbal, Chengxian Zhang, Rendie McHenry, Brent E. Cleveland, Yesenia Romero-Herazo, Chris Fonnesbeck, Daniel C. Payne, James D. Chappell, Natasha Halasa, Oscar G. Gómez-Duarte. Enteropathogenic and enteroaggregative E. coli in stools of children with acute gastroenteritis in Davidson County, Tennessee. Diagnostic Microbiology and Infectious Disease. 2015 Nov;83(3):319-24. doi: 10.1016/j.diagmicrobio.2015.07.016. Epub 2015 Jul 26.

Zorangel Amézquita-Montes, Maria Tamborski, Usa G. Kopsombut, Chengxian Zhang, Octavio S. Arzuza, Oscar G. Gómez-Duarte. Genetic relatedness among Escherichia coli pathotypes isolated from food products for human consumption in Cartagena, Colombia. Foodborne Pathogens and Disease. May 2015, 12(5): 454-461. doi:10.1089/fpd.2014.1881.

Chengxian Zhang, David E. Knudsen, Mei Liu, Donald C. Robertson, Weiping Zhang, the STa Toxoid Vaccine Consortium Group. Toxicity and immunogenicity of enterotoxigenic Escherichia coli heat-labile and heat-stable toxoid fusion 3xSTa(A14Q)-LT(S63K/R192G/L211A) in a murine model. PLoS ONE. 2013, 8(10): e77386. doi:10.1371/journal.pone.0077386

Emad A. Hashish, Chengxian Zhang, Xiaosai Ruan, David E. Knudsen, Christopher C. Chase, Richard E. Isaacson, Guoqiang Zhou, and Weiping Zhang. A multi-epitope fusion antigen elicited neutralizing antibodies against enterotoxigenic Escherichia coli (ETEC) and homologous bovine viral diarrhea virus (BVDV) in vitroClinical and Vaccine Immunology. 2013, 20(7):1076. DOI: 10.1128/CVI.00249-13.

Mei Liu, Chengxian Zhang, Kristy Mateo, James P. Nataro, Donald C. Robertson, and Weiping Zhang. Modified heat-stable toxins (hSTa) of enterotoxigenic Escherichia coli lose toxicity but display antigenicity after being genetically fused to heat-labile toxoid LT (R192G). Toxins (Basel). 2011 September; 3(9): 1146–1162.

Mei Liu, Xiaosai Ruan, Chengxian Zhang, Steve R. Lawson, David E. Knudsen, James P. Nataro, Donald C. Robertson, and Weiping Zhang. Heat-labile- and heat-stable-toxoid fusions (LTR192G-STaP13F) of human enterotoxigenic Escherichia coli elicit neutralizing antitoxin antibodies. Infection and Immunity. 2011 October; 79(10): 4002–4009.

Chengxian Zhang and Weiping Zhang. Escherichia coli K88ac fimbriae expressing heat-labile and heat-stable (STa) toxin epitopes elicit antibodies that neutralize cholera toxin and STa toxin and inhibit adherence of K88ac fimbrial E. coliClinical and Vaccine Immunology. 2010 December; 17(12):1859-67

Weiping Zhang, Chengxian Zhang, David H. Francis, Ying Fang, David Knudsen, James P. Nataro, and Donald C. Robertson. Genetic fusions of heat-labile (LT) and heat-stable (ST) toxoids of porcine enterotoxigenic Escherichia coli elicit neutralizing anti-LT and anti-STa antibodies. Infection and Immunity. 2010 January; 78(1): 316–325

Chengxian Zhang, Dana Rausch, and Weiping Zhang. Little Heterogeneity among Genes Encoding Heat-Labile and Heat-Stable Toxins of Enterotoxigenic Escherichia coli Strains Isolated from Diarrheal Pigs. Applied and Environmental Microbiology. 2009 October. 75(19): 6402–6405

Weiping Zhang, Donald C. Robertson, Chengxian Zhang, Wei Bai, Mojun Zhao, and David H. Francis. Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model. Applied and Environmental Microbiology. 2008 September; 74(18): 5832–5837. 

Sha Cao, Ziduo Liu, Aizhen Guo, Yan Li, Chengxian Zhang, Wu Gaobing, Feng Chunfang, Yadi Tan and Huanchun Chen. Efficient production and characterization of Bacillus anthracis lethal factor and a novel inactive mutant rLFm-Y236F. Protein extraction and purification. 2008 May; 59 (1): 25-30.

Tangming Zhu, Mingxing Guo, Aizhen Guo, Jianjun Chen, Chengxian Zhang, Hui Zhao, Zhenhua Wang, Jiawen Xu, and Xinsheng Xu. Detection of Listeria monocytogenes in exported freshwater food products by a duplex PCR assay. Chinese Journal of Zoonoses. 2007; 23:1234-1237